High Mobility Group A Proteins as Tumor Markers
نویسندگان
چکیده
منابع مشابه
High Mobility Group A Proteins as Tumor Markers
Almost 30 years ago, overexpression of HMGA proteins was associated with malignant phenotype of rat thyroid cells transformed with murine retroviruses. Thereafter, several studies have analyzed HMGA expression in a wide range of human neoplasias. Here, we summarize all these results that, in the large majority of the cases, confirm the association of HMGA overexpression with high malignant phen...
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The quantitative changes of the high mobility group (HMG) nonhistone chromosomal proteins in nondividing, differentiated peritoneal exudate neutrophils were identified by their solubility, electrophoretic mobility on both SDS and acetic acid gels, densitometric traces and elution profile on CM-sephadex. The results indicated that in neutrophils, HMGl undergoes a considerable reduction (80%...
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Viral particles at the late stages of SV40 morphogenesis were examined for the presence of HMG proteins 1 and 2, by an lmmunochemical method involving the transfer of proteins from polyacrylamide gels to nitrocellulose membranes. It was found that these proteins are present in SV40 provirions, in which histone HI is still associated with viral chromatin, but absent in mature SV40 virions. INTRO...
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Nucleosome core particles form well defined complexes with the nuclear nonhistone proteins HMG 14 or 17. The binding of HMG 14 or 17 to nucleosomes results in greater stability of the nucleosomal DNA as shown by circular dichroism and thermal denaturation. Under appropriate conditions the binding is cooperative, and cooperativity is ionic strength dependent. The specificity and cooperative tran...
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Four proteins have been extracted from purified chromatin of wheat embryos with 0.35 M NaCl. These proteins are soluble in 2% (w/v) trichloroacetic acid and thus meet the original operational requirements to be classified as "high-mobility group" (HMG) chromosomal proteins. The proteins have been characterized by one- and two-dimensional electrophoresis, amino acid analysis, and peptide mapping...
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ژورنال
عنوان ژورنال: Frontiers in Medicine
سال: 2015
ISSN: 2296-858X
DOI: 10.3389/fmed.2015.00015